# Aziclar

*Clarithromycin Antibacterial Tablet*

Aziclar is a semi-synthetic macrolide antibiotic containing clarithromycin, indicated for the treatment of various bacterial infections including ENT, respiratory tract, and skin and soft tissue infections. It is also used in combination therapy for the eradication of Helicobacter pylori in patients with gastric or duodenal ulcers.

## Overview

- **Manufacturer:** Ananta Medicare
- **Product type:** Antibiotiques

## Key features

- Inhibits protein biosynthesis by binding to the 50S ribosomal subunit of susceptible bacteria.
- Active against Legionella pneumophila and Mycoplasma pneumoniae.
- Available in 250 mg and 500 mg film-coated tablet dosages.
- Metabolized into the microbiologically active 14-hydroxyclarithromycin.
- Suitable for use in combination therapy for H. pylori eradication.

## Highlights & advantages

### Competitive Advantage

- High in vitro efficacy against a broad spectrum of aerobic and anaerobic Gram-positive and Gram-negative microorganisms.
- Bactericidal effect against Helicobacter pylori with higher activity at neutral pH.
- High tissue concentration in tonsillar and lung tissue compared to blood concentration.

### Clinical Indication

- Streptococcal pharyngitis
- Tonsillitis
- Acute otitis media
- Acute sinusitis
- Maxillary sinusitis
- Pneumonia
- Acute condition of chronic bronchitis
- Folliculitis
- Furunculosis
- Impetigo
- Abscesses
- Cellulitis
- Streptococcal impetigo
- Staphylococcal pyoderma
- Gastric or duodenal ulcer associated with Helicobacter pylori

### Packaging Logistics

- 10 tablets per blister
- 1 blister per carton

## Specifications

| Specification | Value |
| --- | --- |
| Active Substance | Clarithromycin |
| ATC Code | J01F A09 |
| Shelf Life | 3 years |
| Storage Temperature | 30 Celsius |

## Variants

- **Aziclar 250** (Dosage (mg): 250; Tablet Shape: Round, biconvex; Coating Color: Blue): 250 mg clarithromycin film-coated tablet for standard antibacterial treatment.
- **Aziclar 500** (Dosage (mg): 500; Tablet Shape: Oblong, biconvex; Coating Color: Yellow): 500 mg clarithromycin film-coated tablet for severe infections.

## Frequently asked questions

### What is the primary mechanism of action for Aziclar?

Aziclar (clarithromycin) acts by binding to the 50S ribosomal subunit of susceptible bacteria, which inhibits protein biosynthesis.

### Is Aziclar effective against Helicobacter pylori?

Yes, it exhibits a bactericidal effect against H. pylori, particularly at neutral pH, and is indicated for use in combination with other medicinal agents for ulcer treatment.

### Are there specific contraindications for concomitant use with other drugs?

Yes, concomitant use is contraindicated with astemizole, cisapride, pimozide, terfenadine, ergot alkaloids, HMG-CoA reductase inhibitors (lovastatin or simvastatin), oral midazolam, lomitapide, ticagrelor, ivabradine, and ranolazine.

### How should Aziclar be dosed in patients with renal impairment?

For patients with severe renal failure (creatinine clearance <30 ml/min), the dose should be decreased by 50%.

## Documents

- [Aziclar Clinical Study](https://api.dev.mytradeloop.com/storage/4737~G399Rcxk4-JDNXIi) (clinical_study, en, 2p)
- [Aziclar Clinical Study](https://api.dev.mytradeloop.com/storage/4739~37aHYhT84mBF8Nmq) (clinical_study, en, 3p)
- [Aziclar Clinical Study](https://api.dev.mytradeloop.com/storage/4741~NjEiLECDb0810Uz7) (clinical_study, en, 2p)
- [Aziclar Clinical Study](https://api.dev.mytradeloop.com/storage/4743~gxgaui8JtsG8Vcre) (clinical_study, en, 4p)

## Browse placement

- Produits pharmaceutiques et biologiques › Anti-infectieux

## Tags

h-pylori-indicated, macrolide-systemic-antibiotic, clarithromycin, macrolide antibiotic, antibacterial drug, respiratory infection treatment, helicobacter pylori eradication, aziclar 250, aziclar 500

> Made by [Ananta Medicare](https://dev.mytradeloop.com/fr/companies/ananta-medicare-9640). Contact the manufacturer via their profile page.

---

*Source: [mytradeloop](https://dev.mytradeloop.com/fr/products/aziclar-89662). This is the machine-readable (markdown) representation of the page at https://dev.mytradeloop.com/fr/products/aziclar-89662.*